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The Indianapolis Colts host the San Francisco 49ers in a game that two teams with differing ambitions will view as very winnable. Indianapolis does not seem too far from having Andrew Luck back under center and will want Jacoby Brissett to hand the keys back to him with the Colts still in the picture at 2-3 in an AFC South division that remains close but in which the Houston Texans look to be gathering steam.
The 49ers will need stronger quarterback play from Brian Hoyer, who struggled again in their 18-15 overtime loss in Arizona last week. Hoyer went just 24-for-49 for 234 yards and an interception against the Cardinals. Hoyer and the 49ers offense would seem to have an easier task at hand facing the Colts, who have allowed an NFL-worst 34 points per game.
If the Colts are to do some damage against a defense that gave up just one touchdown last week, then it will likely have to be through the air. San Francisco’s secondary has looked extremely questionable in the first four games and Indianapolis’ top receivers T.Y. Hilton and Donte Moncrief are both averaging 17 yards per reception.